Evidence suggests that CBD could play a role in balancing testosterone levels and indicates that it could also stifle the decline of testosterone in the liver. As the cannabis industry grows, more and more people are asking whether or not CBD can lower testosterone levels. Here's what we know so far.
CBD Oil and Testosterone – September 2022
Does CBD impact testosterone levels, and if so, how?
Testosterone is the dominant sex hormone in males. Besides helping maintain a healthy mood, testosterone plays several essential roles.
These roles include the development of the penis and testes, muscle size, strength, sperm production, and sex drive or libido (1 ) .
Testosterone is also one of several androgens (male sex hormones) in females, and they are produced in the adrenal gland and ovaries.
Androgens have significant effects on a variety of bodily functions, such as the ovaries , bone strength, and sexual behavior, including healthy libido.
The proper balance between testosterone (including androgens) and estrogen is vital for the ovaries to work healthily.
While the specifics are uncertain, it is possible that androgens also play a critical role in normal brain function, including mood, sex drive, and cognitive function.
A testosterone levels test measures the levels of testosterone in the blood. Testosterone levels that are either too high or too low can cause health problems in both men and women . (2 )
CBD and Testosterone: The Role of the ECS Explained
The endocannabinoid system (ECS) is a system of the human body which includes the naturally-produced cannabinoids.
Among its many critical bodily functions is its vital role in reproduction , which is essential to consider when discussing CBD (cannabidiol) and testosterone (3 ) .
The ECS is also one of the primary regulatory feedback mechanisms in the hypothalamic-pituitary-gonadal (HPG) axis. When CB1 and CB2 receptors are triggered, the reproductive hormones are also signaled and activated (4 ) .
However, unlike THC (tetrahydrocannabinol) , CBD does not directly bind to the CB1 and CB2 receptors. Instead, it indirectly impacts the ECS through other neurotransmitter systems present.
The binding of cannabinoids to either receptor can have adverse effects on the male reproductive system.
Evidence suggests that CBD could play a role in balancing testosterone levels.
In one of the earliest research on CBD and testosterone, researchers found that male sexual and reproductive function in animal models could be affected not only by THC but also by CBD (5) .
In a study published in Molecular and Cellular Endocrinology , the researchers noted that CBD might reduce the generation of testosterone in rats but the effect was worse with THC (6 ) .
The results also indicated that CBD could stifle the decline or oxidation of testosterone in the liver.
CBD, however, cannot lower the already-circulating serum testosterone levels in the blood, as shown in a study , published in Drug Metabolism and Disposition, that was conducted in rats (7 ) .
Ultimately, testosterone production reverts to its natural state when CBD is no longer present.
CBD’s Impact on Testosterone Levels
According to the American Psychological Association, ongoing stress over an extended period can affect testosterone production, resulting in a decline in sex drive or libido. It can even cause erectile dysfunction or impotence (8 ) .
Meanwhile, studies have shown CBD’s therapeutic benefits that might impact testosterone levels by helping the body produce more of the hormones.
A study published in the Journal of Psychopharmacology demonstrated CBD’s anti- anxiety characteristics (9 ) .
The authors noted that CBD could be a useful addition to treatment plans for both social and general anxiety disorders.
By limiting the amount of emotional stress individuals feel, they can help their body produce testosterone.
When stress affects the immune system , the body can become vulnerable to infection. In the male anatomy, infections to the urethra, testes, and prostate gland can impact male reproductive functioning (10 ) .
Meanwhile, research has demonstrated that cannabinoids, like cannabidiol, can interfere with the release of cytokines (11 ) . Cytokines are proteins involved in acute and chronic inflammation (12 ) .
Also, the essential fatty acids found in hemp extracts, like CBD oil, have been shown to help increase testosterone production.
A year-long study published in the Asian Journal of Andrology examined the link between fat intake and reproductive hormone levels among healthy human subjects (13 ) .
The study found a positive correlation between the ingestion of polyunsaturated fats, like omega-3 and 6, and hormone concentrations.
Ultimately, results showed that subjects who increased their intake of essential fatty acids experienced improved testicular function, which likely helped improve their levels of production of testosterone.
Most experts recommend that individuals looking to improve their testosterone levels naturally should focus on prioritizing sleep , eating a healthy and balanced diet, maintaining a healthy weight, exercising regularly, and finding ways to reduce stress.
CBD can be utilized in all of these measures, as the potent cannabinoid has been shown to possess several therapeutic benefits that may help manage and improve testosterone levels.
Still, before embarking on a CBD regimen or including it as an adjunct therapy, consult with a doctor experienced in cannabis use for advice.
Cannabis and Testosterone: Does CBD Lower Testosterone?
Cannabidiol (CBD) is the hot-favorite cannabinoid of the cannabis plant, loved by people all across the globe. This obsession is for several reasons, mainly because of CBD’s huge plethora of benefits. CBD’s exceptional potential to improve the quality of life has led users to wonder if CBD affects testosterone or does CBD lower testosterone.
CBD can closely interact with your body’s endocannabinoid system, which supervises and controls multiple mechanisms, including hormonal production. A lot is happening in your body, and hormones have most of the charge over your body’s mechanisms.
Ever wonder how your body manages to operate in harmony day after day? Yes, you got it right. It’s all about those hormones helping your body communicate well. Testosterone is a significant male hormone that regulates sperm production, sex drive, and several other functions. 
Our expert analysis brings forth several facts regarding the relationship between CBD and testosterone. This write-up is all about our diligent research on the most frequently asked question; Does CBD increase or decrease testosterone? Stick around to learn more.
What Is Testosterone?
Just like other hormones, testosterone is a chemical messenger that operates in your body to induce certain physical and chemical changes in the body. You might be wondering if testosterone production is confined to male bodies, but that’s not the case. Females produce testosterone as well but in a comparatively smaller amount.
Males have Leydig cells in their testicles that are typically involved in the production of testosterone. There are a plethora of functions accomplished by testosterone in men’s bodies. Some of the following are:
Production of sperm
Sexual arousal and sex drive
Distribution of fat in different parts of the body
Maintenance of bone mass
Development of muscles and promotion of increased strength
Production of new red blood cells in the body.
If your body fails to produce sufficient amounts of testosterone due to any persisting health factor, you may become infertile. The major reason is that testosterone helps you produce healthy sperm. On the contrary, if testosterone production increases in women, it might lead to infertility.
Also, to understand everything better, it’s substantially important to know the sites where testosterone is produced in your body. The pituitary gland and the brain critically govern the level of testosterone in your body.
CBD’s interaction with Hormones
Let’s discuss the link between cannabis and testosterone, or more specifically, at what points does cannabidiol interact with the maintenance of hormonal levels. There are a few ways that CBD may impact, enhance, or diminish the production of certain hormones in your body.
Production of hormones:
The glands in your body are fully covered with cannabinoid receptors, which the endocannabinoid system directly controls. CBD interacts with the ECS and cannabinoid receptors of the body. This ultimately empowers CBD to have an indirect charge over the production of hormones as well. This way, it can alter the patterns of hormonal production and impact the organs.
Mostly when the CB1 receptors are activated, the whole process is initiated by the hypothalamus, which has charge over hormonal synthesis. Ultimately a series of chemical messages are forwarded to other glands that trickle down and trigger the production of hormones as a response.
CBD possesses a remarkable ability to influence, diminish or enhance the volume or strength of the hormonal message sent to the glands for triggering them to produce hormones. Also, it can impact the sensitivity level of the receptors in the glands.
This way, CBD can influence the “response” mechanism of the Respective hormonal glands to increase or decrease the production of various hormones. Experts believe that this is exactly how CBD can impact the production of hormones.
Breakdown of hormones
How Does CBD Affect Testosterone Level?
Several studies bring forth different factors that need to be arranged in order to better comprehend the effects of CBD on production.
Does CBD lower testosterone? According to the results of a recent experiment on monkeys, CBD was found to increase the production of LH and FSH hormones. The doses used were a lot higher than people generally consume. However, surprisingly there was no change in testosterone level until the dose was exceptionally increased to an unrealistic level. It displays that CBD doesn’t show any substantial impact on the level of testosterone. 
The following studies suggest that CBD may reduce the production of testosterone in the body.
CBD was shown to have adverse effects on testosterone production in mice and rats. However, this experiment involved extensively high doses of CBD that are practically not used. 
An enzyme called 17α-hydroxylase actively produces testosterone in the testes. CBD can directly inhibit this enzyme, thereby preventing testosterone levels from declining.
Medical science potentially lacks proper literary work to elaborate on the effects of CBD on human beings. We need more practical trials on humans to have more explicit results in this regard.
Does CBD Increase Testosterone In Any Way?
One important point to consider is that all the studies that support the concept of CBD inhibiting testosterone levels have used extremely high doses of CBD. Also, as testosterone levels are also decreased by stress and inflammation, CBD might help improve the production of testosterone through its assistance in fighting off stress and inflammation in the body.
With all this said, we recommend you to exercise regularly and not consume extensively high doses of CBD. Make sure to track your doses and give yourself frequent breaks to revive the body’s regular production of hormones.
For those still wondering does CBD lower testosterone? CBD doesn’t show any substantial impact on reducing testosterone production in human beings if used in average doses.