CBD Oil Suppository


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Created for Anal and Vaginal Sex. These suppositories relax your muscles allowing deep penetration and promote blood flow —HELLO ORGASM. The back door is making a comeback – medically speaking. Cannabis oil suppositories have grown in popularity, but how and to what extent they actually work remains somewhat of a mystery.

Mello Bottoms ~ CBD Suppositories

Before you say, “you want me to put what in where ?” just hear us out. We know suppositories probably weren’t the first thing you thought of when you started looking up ways to get your CBD dose. We’re willing to bet they weren’t your second, or third, or even fourth thought either. People are afraid to talk about them — but not us.

Etch out some time in your calendar to unwind, and then let the Mello Bottoms take you there! A total relaxation. Get intimate. Enjoy Sex!

These make it easy for you to administer your CBD dose. Since CBD has greater bioavailability and absorption when administered in this manner, Your 75mg dose hits in just 10 minutes. Bottoms up, baby.

  1. Wash hands with soap and warm water.
  2. Remove suppository from the fridge and remove wrapper.
  3. Lubrication is key! Apply a water-soluble lubricant to the application area as well as to the tip of the suppository.
  4. Insert in your vagina or your bottom. We personally prefer our booty hole.
  5. Wash your hands thoroughly.
  6. Rest for 5-20 minutes so the suppository can settle in and won’t slip out.
  7. Enjoy the relaxation!

For anal insertion, lie on your side and straighten your lower leg while bending your upper leg toward your stomach. Lift upper buttock, and insert the suppository until it passes the muscular sphincter of the rectum — this is about 1 inch in most adults!

For vaginal insertion, insert the suppository (pointed end first) with your finger as far back as it can go without causing any discomfort.

Organic Coconut Oil

Full Spectrum Cannabis Hemp Extract with CBD

Organic Hemp Oil

Organic Cocoa Butter

75MG of CBD per Suppository

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. more

Orders are processed and shipped Monday through Friday from 9am to 5pm EST (excluding holidays) with 5-7 business-day delivery on all US orders with our flat rate shipping.

If placed after 5pm on Friday, the order will be fulfilled the following Monday.


Research shows that CBD increases the serum concentration of anandamide. Anandamide is very closely related to the hormone oxytocin, commonly known as the cuddle hormone. This can provide for a deeper emotional connection during intimacy.


A recent study conducted on adults showed that CBD can relax your muscles, and improve blood flow. It also opens your nerve receptors increasing the intensity of orgasms.

It has been proven that CBD can help relax the uterine muscle where cramps occur, decrease inflammation and pain in our body, and help with anxiety, mood swings, and irritability during our period.

Why CBD Suppositories?

Suppositories have the highest bioavailability ~94%. The reason doctors don’t prescribe all drugs this way is that oral dosing is more convenient, and people are weird about putting things in their bums.

Simply put bioavailability refers to how much CBD will be absorbed, how quickly you feel the CBD, and how long the Body Bliss lasts.

  1. Almost all of the CBD is absorbedA recentstudyshowed that 94% of paracetamol was absorbed when administered rectally, compared to 37% when administered orally. Unlike a capsule, this method bypasses the stomach, intestine, and liver where it will most likely be eliminated.
  2. A CBD suppositoryis absorbed fast —It immediately enters the bloodstream through the large veins in your bottom . It moves from the bloodstream to the tissues and cells and binds to receptors, and gets to work. There is no waiting for it to make its way through your digestion, it is instant.
  3. These can last up to 24hours as it takes longer for your body to metabolize CBD when combined with a fatty acid, in this case we chose Coconut Oil.

Also knowns as early-onset. Are you tired of waiting for your CBD to hit? Now you do not have to!


94% of CBD will be used. Isn’t it time for you to get what you paid for?


Your Questions, Answered.

Seriously. Our team of Cannabinoid Connoisseurs has done the research.

WHY Suppositories?

We think it’s crucial to have open conversations around sexual health. When we say sexual health, we are not just referring to vaginal penetration, anal penetration should also be included in this conversation. Both should be pleasurable, and not painful.

To anyone who has struggled with painful sex— whether from Endo, PMS, or Vulvodynia, or Anal— you know that there is a shame and fear that accompany it. Our founder personally struggled with this for a long time.

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So, she created Mello Bottoms— a CBD suppository for Sex. The reality is that everyone is doing it, we just aren’t talking about it. With Mello, we hope to lead that conversation.

How do they work?

The warmth of your body melts the oil and CBD is absorbed through the large juicy blood vessels in your bottom, and then sent to your bloodstream.

Why are suppositories a preferred absorption method?

Because they treat the local area, but also bypass ‘the first pass effect’ and allow cannabinoids to absorb directly into the bloodstream— Two hits in one.

Essentially everything you consume, a capsule, oil or edible has to make its way through your GI tract and into your liver, and then into your bloodstream. This process takes time and along the way your body eliminates a lot of it. It is also unique to every person. Taking a suppository removes these variables. They bypass that step entirely and absorb directly into your bloodstream through the veins in your bottom or vagina. So you get more of the cannabinoids you paid for. And you feel the effect much faster.

They take effect in about 10 minutes— Perfect time for a little foreplay and intimacy before penetration.

But Why Use CBD for intimacy?

Studies have shown that CBD can elevate your mood and decrease inhibition.

Studies have proven that CBD inhibits inflammatory and neuropathic pain responses.

PMS? PCOS, Vulvodynia?

Vulva pain, PMS and PCOS all cause awful cramping, and muscle aches and pains. Which comes from inflammation, in most cases if you can treat the local area and remove the inflammation. The pain does decrease.

Can you use them in your bottom or your vagina? Which one is better?

Ultimately this is a personal preference. I like to think of my vagina as a beautiful machine I want to leave alone, so I take them through my bottom. But it does not matter. Your bottom or your vagina. They both are richly vascularized (ahem veiny) so will absorb the cannabinoids either way.

Is it difficult to use the suppositories?

Frankly it is way easier than you think. Your bottom tends to suck them in, once you are in a comfortable position and have lubed up accordingly, you only need to insert the tip and your bottom takes care of the rest.

Anal Sex Prep, Is there anything I need to do differently?

You should do the usual prep you are comfortable with doing prior to having anal. And then when you are with your partner and ready to play, take one. Think of these as the item you insert just prior to your foreplay. Do it together, enjoy the moment.

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© 2022 Mello Daily This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited by Law. Powered by Shopify

Do Cannabis Suppositories Work?

The back door is making a comeback – medically speaking.

Cannabis suppositories have grown in popularity, but how and to what extent they actually work remains a mystery. With contradictory claims from proponents and skeptics regarding the rectal bioavailability of THC , intoxication (or lack thereof), and alleviation of symptoms of difficult-to-treat diseases, it’s time to get a grip on what we really know about this method of administering cannabis.

Clinical research on cannabis suppositories is still limited. Much of the available data pertains to experiments conducted on animals, not on people who actually use suppositories. Despite the distinct lack of clinical studies, anecdotal accounts from patients are often very positive. The overwhelming majority of patient reports have one thing in common: a lack of intoxication that’s typically caused by smoking or ingesting THC -rich cannabis.

The absence of a “head high” would seem to indicate that a suppository does not distribute a systemic dose of cannabis – which corroborates initial research findings about limited bioavailability. This suggests that a suppository acts more like a topical with a local effect, rather than a transdermal patch which disseminates medicine systemically through the bloodstream.

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Why suppositories?

Rectal and vaginal suppositories have both been used to deliver medicine to patients for decades. The pelvic region houses a matrix of nerves that travel to the legs and up the spine, and the colon contains cannabinoid receptors ( CB 1 and CB 2), which mediate many of THC ’s effects.

Generally, cannabis suppositories are made by combining cannabis-infused oils in a carrier oil that hardens at low temperatures. Rectal administration of cannabis oil may activate the cannabinoid receptors located there, which could be beneficial for local conditions like hemorrhoids or acute inflammation [6]. The rectum also contains a number of key veins that deliver blood to the entire body, but it doesn’t appear that suppositories facilitate cannabinoid absorption into the bloodstream.

Even if they are only effective locally rather than systemically, suppositories may offer a viable alternative to patients suffering from conditions that render them unable to ingest their prescriptions orally [1]. Issues with palatability, severe nausea or vomiting, compromised esophageal or gastrointestinal tracts, and a range of other symptoms can make oral administration an impossibility for many patients.

Clinical research

A number of studies have called into question the rectal bioavailability of THC . In a 1985 study, researchers found no circulating levels of Δ9 THC in blood plasma after rectal administration of THC . According to University of Mississippi pharmacologist and researcher Dr. Mahmoud ElSohly, this means that in commercially available formulations THC is not absorbed into the bloodstream via the rectum at all.

ElSohly claims that any cerebral intoxication experienced using cannabis suppositories is a result of the placebo effect rather than the activation of the CB1 cannabinoid receptors in the brain – which is what makes us feel high from THC .

Interestingly, a later study showed that a chemically modified version of THC , called THC -hemisuccinate (or THC – HS for short), is bioavailable in the rectum. Succinate, an intermediate compound in the breakdown of sugar, is slightly water soluble, which allows it to be absorbed through the rectal mucosa. It was first synthesized at ElSohly Laboratories, Inc. Unlike regular THC , THC from the hemisuccinate ester was found to easily permeate and absorb into rectal mucus membranes [7], then enter into circulation as Δ9 THC . As a result, most of the THC avoided first-pass metabolism and did not transform into its more psychotropically potent metabolite, 11-hydroxy- THC , in the liver [5].

“ElSohly claims that any cerebral intoxication experienced using cannabis suppositories is a result of the placebo effect.”

The results from a follow-up 1996 pilot study support the idea that THC – HS administered rectally could result in improvement in symptoms of spasticity, rigidity, and pain, while producing no measurable differences in cardiovascular function, concentration, and mood of the participants – in other words, without signs of measurable intoxication.

Most recently, in 2018, ElSohly and his team found that the concentration of Δ9 THC in blood plasma after rectal administration of a THC – HS suppository was about 70-80% bioavailable, almost 2.5 times higher than an orally ingested THC capsule. While there were no reports of intoxication for the test subjects, the paper states that first-pass metabolism was “greatly reduced,” although not eliminated entirely. This means that some slight psychotropic effects from the 11-hydroxy- THC could still be possible with THC – HS formulation, but more studies are necessary to confirm this.

ElSohly’s research could have significant implications for cancer patients and others suffering from conditions that may require very high doses of cannabinoids but who are unable to smoke or ingest their medicine. THC – HS , however, is a patented molecule and can only be prepared with a license from the University of Mississippi.

Pain relief and pleasure

Cancer patients* and people with compromised upper alimentary tracts will likely have to wait some time before THC – HS formulations become commercially available. Meanwhile, THC and CBD -rich suppositories are currently being sold in state-licensed cannabis dispensaries.

Ben Odell, content director at Foria Wellness, a cannabis producer based in California and Colorado, says that the best way to conceptualize the effects of suppositories is by imagining them as powerful topicals – except they are applied internally. Just as externally applied topicals interact with cannabinoid receptors in the skin, rectal suppositories are aimed at nerve endings and cannabinoid receptors in colonic tissue.

“Everyone is debating and discussing rectal absorption of THC , and whether [cannabis oil extracts] and other formulations are absorbed into the bloodstream or not. But we’re not interested in getting people high,” says Odell. Instead their focus is on creating products that alleviate pain and discomfort in the lower body, as well as products that enhance intimate pleasure.

“Odell says that customers and Foria staff have been experimenting with cannabis suppositories for relief of other lower-body issues, like cramping, inflammation, and pelvic discomfort – with good results.”

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Foria initially launched their mixed THC : CBD ratio rectal suppository as a sexual aid. “We were hearing from our friends in the queer community that a lot of people use nasty chemicals to relax the anal sphincter before sex — things like ‘poppers,” Odell told Project CBD . The idea behind the new product line is that THC and CBD could help mitigate painful localized inflammation and relax smooth muscle tissue – like the involuntary muscle tissue of the internal sphincter [9]. Odell says that customers and Foria staff have been experimenting with cannabis suppositories for relief of other lower-body issues, like cramping, inflammation, and pelvic discomfort – with good results.

Foria also produces a high- CBD suppository and a high- THC formula for vaginal application. Odell reports that feedback regarding THC -rich suppositories has been far more positive for pain relief than the CBD line. This summer Foria will be partnering with Harvard neuroscientist Dr. Staci Gruber to conduct a study that will track women’s responses to CBD suppositories.

Who can benefit?

Whether or not cannabinoids are absorbed into the bloodstream from the rectum, many suppository enthusiasts report powerful, localized, non-psychotropic effects for a range of middle and lower body afflictions.

Anal Suppositories

Men and women have reported using rectal suppositories to treat anal fissures, hemorrhoid inflammation, digestive issues, Crohn’s and IBS , sciatica, restless leg syndrome, lower back pain, prostate issues, and post-operative pain. Rectal suppositories are also being used for lubrication to mitigate pain during anal intercourse.

Vaginal Suppositories

Vaginal suppositories have been used to ease menstrual cramps, abdominal pain, endometriosis, pelvic discomfort, post-coital pain or inflammation, vaginal dryness and pain with intercourse, as well as for relaxation and sexual enhancement.

Of course, dosing via the vagina or rectum is not as simple as taking a puff or swallowing a pill (lest we forget about gravity). Cannabinoids are tricky molecules and there’s still much to learn scientifically and pragmatically about the efficacy of various delivery systems, including cannabis suppositories.

Thus far, clinical studies have shown no rectal bioavailability of unadulterated THC [2,7]. And while it’s plausible to speculate that cannabinoids could have an effect via local pathways in the colon and elsewhere, those pathways haven’t been studied yet. Although many anecdotal reports are positive, there are some significant discrepancies in observed efficacy [9]. Far more research is needed to better understand exactly how this method works (or doesn’t).

But there’s no need for patients to wait until all the results are in. If you’re curious, suppositories could be worth a try. You probably won’t get a “head high,” according to the legendary Tommy Chong, who uses cannabis suppositories under a doctor’s supervision. Though you might feel a little “butt high,” Chong says with a smile, which is not necessarily a bad thing.

How To Make Your Own Suppositories

If you want to try suppositories at home, you have a few options: you could find them at your local dispensary, order online, or make them yourself with a few simple ingredients.

What You Need

  • Full-extract cannabis oil of your choice
  • A base (organic cacao butter or coconut oil are recommended)
  • Suppository molds (these can be metal, silicone, or plastic)


  • Gently heat the base in a pan.
  • Add in the cannabis oil of your choice and mix well.
  • Pour the mixture into the suppository mold and pop it into the freezer.

Tips and Tricks for Use

  • While the onset of effects is highly variable, users typically report feeling effects within 30-60 minutes for vaginal application and 15-30 minutes with rectal administration.
  • The base will melt quickly during contact with warm skin, so keep the suppositories in the freezer until you’re ready to medicate.
  • You can prevent leakage by lying in a horizontal position during insertion and for at least 15-30 minutes after.
  • Try using them at night your first few times. It’s always better to be familiar with potential effects before daytime use.
  • Record your experiences in a journal to identify your patterns and best practices.

(Recipe courtesy of Paula-Noel Macfie)

* Suppositories are not reccomended for use by cancer patients undergoing chemotherapy. According to Dr. Bonni Goldstien, “chemo causes thinning and sloughing of cells of the lining of mucus membranes (which is the tissue of the mouth and rectum) and also decreases the ability of the immune system to fight infection” and inserting a suppository could introduce infection-causing bacteria.

Jelena Grove is a cannabis writer and budtender based in Portland, OR . This is her first article for Project CBD .

Copyright, Project CBD . May not be reprinted without permission.

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