CBD Oil For Dry Eyes

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Cannabis CBD eye drops There are at least 113 different cannabinoids that have been isolated from the cannabis plant. The most notable, are THC and CBD. THC exerts its effects by binding to Are you worried about whether CBD will give you noticeably red or dry eyes? Here are the factors you’ll want to understand about CBD’s effects!

Cannabis CBD eye drops

There are at least 113 different cannabinoids that have been isolated from the cannabis plant. The most notable, are THC and CBD.

THC exerts its effects by binding to CB1 and CB2 receptors in humans. CBD does not act on the cell wall, but rather inside the cell. It is for this reason that CBD has no addictive potential, no psychoactive activity, no withdrawal, and no toxicity.

CBD has multiple health benefits for insomnia, anxiety, depression, seizures, autism, pain, social anxiety, addiction, and many more. Recent studies show that CBD can also help in the treatment of some eye conditions.

CBD is alleged to be particularly beneficial on the eye due to its neuroprotective effects. Preventing apoptosis of the optic nerve cell can preserve vision, the ultimate goal in the treatment of all diseases of the eye.

The challenge of using a topical cannabis product on the eye

CBD is a natural oil, and as such, is lipophilic. The cornea which is the first layer of the eye is coated with a hydrophilic layer. On a mechanistic level, it is challenging for an oil-based substance to successfully pass through the water-based liquid lining the cornea and penetrate the eye.

One idea that is being investigated is the use of liposomes. Liposomes have hydrophilic heads and hydrophobic tails that line themselves up into a sphere. Current studies have demonstrated that topically applied CBD in a liposomal formulation can successfully penetrate the hydrophilic layer that lines the cornea.

Why use topicals cannabis product when there are other delivery systems available?

Topicals will eliminate all systemic side effects and maximize the dose delivered to the eye.

The problem, as with all topicals, is that less than 5% of any dose delivered reaches the intraocular tissues. The surface of the eye is moistened by fluid which is constantly flushing the surface of the eye and drains out through the lacrimal duct. In addition, any medication administered must first penetrate the hydrophilic layer that coats the cornea and following that, the lipophilic corneal lining.

CBD and corneal abrasions

When the cornea is damaged, there is intense pain due to a dysfunction in the sensory receptors that line the cornea. As a result of the physical disruption from the abrasion, intense inflammation develops. Both THC and CBD can provide analgesic and anti-inflammatory benefits, but THC is limited due to its psychoactive effects which may include dysphoria, disruption of short-term memory, cognitive impairments, sense of time distortion, and reduced coordination. CBD however, can provide the analgesic and anti-inflammatory benefits without any psychoactive side effects.

What ultimately causes visual loss and how can cannabinoids prevent it?

Visual loss is caused by ischemia of the optic nerve – which is seen in diabetic retinopathy, or by increased pressure on the optic nerve, essentially crushing the nerve – which is seen in glaucoma.

Cannabinoids decrease ischemia and improve oxygen delivery to the optic nerve by decreasing glutamate release. Glutamate activates NMDA receptors which cause calcium influx into cells, frees radical generation, and subsequent cell death. CBD can prevent the death of nerve cells by scavenging the toxic reactive oxygen radicals released by glutamate activation.

In glaucoma, there is increased intraocular pressure which eventually crushes the optic nerve. Cannabinoids have vasorelaxant properties and as a result, decrease the intraocular pressure by dilating the capillaries thus promoting increased exit flow of the aqueous humor.

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What medical benefit does CBD offer that other topical agents do not?

As an example, the most common ocular injury – corneal abrasions, is treated with a myriad of agents which include topical corticosteroids, tricyclic antidepressants, opioids, and agents that stimulate the GABA receptors. All of these pharmacotherapeutic agents are suboptimal and have side effects.

Studies were performed on mice models given experimentally induced corneal surface injuries. When topical CBD was administered, corneal pain and inflammation were reduced via activation of the 5-HT1A receptor. CBD provides adequate pain relief and reduces the inflammation and does so without any of the side effects seen in conventional agents.

CBD & diabetic retinopathy

Diabetic retinopathy is one of the retinal diseases associated with vascular neuroinflammation. It is the leading cause of blindness in the Western world and treatment options are very limited.

Diabetes causes superoxide formation which leads to the release of adenosine and pro-inflammatory cytokines. In preclinical studies, CBD was found to block superoxide formation. CBD produced the antioxidants that reduced the inflammation in the damaged retina of the diabetic.

CBD and dry eyes

The major cause of dry eyes is a dysfunction of the meibomian gland. The meibomian gland is located behind the eyelashes on both the top and lower eyelids. The fatty substance they produce slows the evaporation of the tears. This lack of oil production results in inadequate tear production with the clinical manifestation of dry eyes. CBD applied topically can help restore the function of the meibomian glands and reduce dry eyes.

Another cause of dry eyes is corneal neuralgia – also treated by CBD. In corneal neuralgia, the corneal nerves become dysfunctional and send pain signals to the brain that are out of proportion to the physical insult, if indeed there is any injury at all. The brain perceives the sensation known as ‘dry eyes.’ CBD applied topically eliminates the neuralgia of the pain felt from the dry eyes.

Future research on CBD and Cannabis eye drops

Work is underway to find the best microemulsions and cyclodextrins so that CBD, a lipophilic agent, can penetrate the hydrophilic aqueous fluid that continually washes the surface of the cornea.

Take home points about Cannabis CBD eye drops

Inflammation leads to damage to the cornea, uvea, retina, and ultimately to the optic nerve.

When inflammation is not blocked, it leads to apoptosis of the optic nerve or death of the cell, in other words – blindness.

CBD can address the inflammation and we believe, can help prevent the endpoint of all ocular diseases which is blindness.

About Cannabis GxP consultancy

Cannabis GXP is an Israel-based consultancy firm working within the cannabis industry.

We are currently engaged in revolutionizing the world of cannabis and hemp cultivation, production and regulation, and are reaching out to growers and manufacturers across the world who wants to join this amazing ride.

We are proud to stand at the forefront of the GMP standards and regulation fields in Israel and worldwide.

Our team is compelled to spread the message of the importance of cannabis regulation and standardization as the world enters a new era of cannabis legislation.

We aim to position our clients with their best foot forward when it comes to anything and everything cannabis related.

We assist companies and growers with facility design, Quality Assurance, Good Practices (GAP/GMP/GLP/GDP), training, and dealing with local and global regulation. Cannabis GXP strives to assist our clients with the development, manufacture and distribution of pharma-grade cannabis products, with a strong emphasis on safety, efficacy, and professionalism.

Cannabis GXP is a subsidiary company of Bio-Chem Ltd. (2007) – a consultancy company for Pharmaceutical, Medical Devices, Cosmetics, and Supplements, based in Israel (http://bio-chem.co.il/en/home/)

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Some of our esteemed clients: Teva, Tikun Olam, J&J, Weizmann Institute of Science, BOL pharma, Seach, Nuuvera, Gamma-Cert, Cannabillis, Monsanto, Evogene, Collplant, Sigma-Aldrich, and many more.

Our Cannabis consultancy services include:

  • Investigational Cannabis product development and clinical trials
  • Cannabis growing & manufacturing facilities design
  • Cannabis Quality Assurance & Good practices (GxP)
  • Cannabis product manufacturing technology
  • Cannabis product regulation & FDA/EU submission
  • Novel Cannabis APIs and product delivery systems

References:

“Intraocular distribution of topically applied hydrophilic and lipophilic substances in rat eyes.” Drug Delivery. 2016 Oct;23(8):2765-2771.

Increase in aqueous solubility, stability and in vivo corneal permeability of anandamide by hydroxypropyl-β-cyclodextrin.” Int J Pharm (1996); 137:209–17.

“Anti–Inflammatory Effects of Cannabinoids in Endotoxin–Induced Uveitis.” Investigative Ophthalmology & Visual Science May 2005, Vol.46, 972

“The Non-psychoactive Phytocannabinoid, Cannabidiol (CBD), and the Synthetic Derivatives, HU308 and CBD-DMH, Reduces Hyperalgesia and Inflammation in a Mouse Model of Corneal injury.” FASEB Journal of Pharmacology Published Online: 1 Apr 2017 Abstract Number: 811.7

“The Cannabinoids Δ 8 THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation.” Cannabis Cannabinoid Res. 2018; 3(1): 11–20.

“Anti–Inflammatory Effects of Cannabinoids in Endotoxin–Induced Uveitis.” Investigative Ophthalmology & Visual Science May 2005, Vol.46, 972

“Neuroprotective Effect of(−)Δ 9 -Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity: Involvement of Peroxynitrite.” The American Journal of Pathology Volume 163, Issue 5, November 2003, Pages 1997-2008

“Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-κB involvement.” Neuroscience Letters Volume 399, Issues 1–2, 15 May 2006, Pages 91-95

“Turning down the thermostat: modulating the endocannabinoid system in ocular inflammation and pain.” Front Pharmacol. 2016;7:304

CBD Oil For Dry Eyes

Cannabis, especially marijuana, is often associated with red eyes in the collective imagination , especially regarding smoking. Marijuana smokers can often be easily identified by the red rings around their eyes, along with characteristics like drowsiness, euphoria, and sometimes excessive hunger also called the munchies. However, people need to understand that THC, not CBD, causes inflamed, watery, and red eyes. But why is that the case? And will CBD ever make your eyes red or dry?

Our cannabis and CBD experts at Care Division are here to explore these essential questions to help you better understand the impacts CBD has on your body. Please continue to learn everything you’ll need to know about the issue, and also consider exploring our selection of other educational CBD resources for even more information. We’re proud to provide people not only with top-quality CBD products but critical knowledge about CBD as a whole.

Why Doesn’t CBD Cause Red or Dry Eyes?

You’ll first want to understand that CBD will not turn your eyes red or dry, no matter how much you smoke, consume, or put on your body, because it doesn’t cause the same effects as THC. They are two different cannabinoids that trigger a diverse range of symptoms in those who smoke or consume them, despite being found in the same plant. To better explain the situation, let’s delve into the primary differences between THC vs. CBD .

The Basics of THC

THC is the well-known psychoactive component of cannabis that results in a sensation of being “high” or euphoric, but it also causes other symptoms, including red, irritated eyes. This effect occurs because THC dilates blood vessels and lowers blood pressure while ultimately causing the usually small, unnoticeable blood vessels in the eyes to appear more prominent. The higher blood flow in the eyes then triggers excess redness, watering, and irritation, creating the telltale look associated with marijuana smokers. However, the smoke produced from marijuana pipes or joints may also exacerbate eye redness and irritation.

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The Basics of CBD

In contrast, CBD is a nonpsychoactive cannabinoid that will not get users high and instead produce a range of other, often beneficial symptoms . CBD is often used to help people relieve pain, relax, and sleep well without altering their mental states. It also doesn’t cause the same effects on blood vessels as THC or cause blood to rush to the eyes. If someone smokes or consumes CBD or CBD-based products, those around them are not likely to notice, as they likely would when someone smokes or consumes THC.

However, please keep in mind that too much of anything can be bad for you, so be sure you don’t go overboard. Just because it’s harder for others to tell if you’ve been smoking or consuming CBD products compared to THC ones doesn’t mean you should go too far. Consider reading our specialized guide on how much CBD is too much and the effects it can cause to learn more.

With so many different CBD products on the market, it can be hard to find the best ones to try first! Care Division can help save you some time by offering access to a wide array of top-quality CBD tinctures, topicals, and beauty products you won’t find anywhere else!

Used CBD and Still Got Red, Dry Eyes? You May Have Been Scammed

If you’ve ever smoked CBD or consumed a CBD product that you thought was THC-free and still ended up with red, irritated eyes, then it wasn’t actually THC-free. Throw the product out right away if you genuinely don’t want to deal with those effects or have THC in your system.

Try using eye drops to relieve the inflammation, and consume things like coffee, chocolate, and salt to help narrow your blood vessels. You’ll generally need to be patient and wait for the issue to resolve itself , but those tactics can sometimes help speed up the process.

You always want to be careful about where you get your products, what brand they belong to, how much they cost, and other critical factors that can help you determine the quality of the product. You’re more likely to encounter this kind of issue if you get your CBD from a friend or an uncertified seller, so always be sure you’re getting your flower and other products from quality, trustworthy sources, like Care Division.

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