CBD Oil For Dogs With Lymphoma

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Looking for alternatives to manage canine lymphoma? This article discusses CBD oil and how this product may help relieve your furry friend's lymphoma symptoms. No one wants to discover that their dog has lymphoma, the most common kind of cancer in dogs. Unfortunately, it is the reality for many pet owners. If you have already learned that your dog has lymphoma or fear that it does, read this blog post to learn about the disease and how CBD oil for Lymphoma in dogs may allevia

Compare the Best CBD for Lymphoma in Dogs for 2022

Spruce’s dog-friendly CBD has been specially formulated for dogs. Instead of hemp seed oil for the carrier oil, the product contains coconut oil, which is generally easier on the digestion for dogs. The taste is also milder with no flavorings, making it more likely that dogs will eat it with their food.

Using Spruce CBD for dogs is simple. All owners have to do is sprinkle the desired dose on the dog’s food at mealtime once or twice a day. Each dose should consist of about two to three drops per 20 pounds of dog weight.

2. Honest Paws Wellness Oil for Dogs
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Product offering is extensive

Most products were not tested for solvents or mycotoxins

Products are made from 100% organic, non-GMO, and locally grown hemp

Limited information on the company

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Available in the US only

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A calming full-spectrum hemp oil that combines naturally occurring CBD with other ingredients for healthy immunity, calm moods, and a healthy brain.

3. Nuleaf Naturals Pet CBD Oil
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No other flavors

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CBD for dogs, cats and other four-legged friends! Our product is concentrated to approximately 50mg cannabinoids per milliliter of oil. While this product is designed for pets, it’s great for humans, too.

4. 4 Corners Cannabis Pet Tincture
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Has a wide variety of CBD strengths

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4 Corners Cannabis Pet Tinctures are generous on their options since there are different sizes and strengths available for you exact needs. The flavor peanut butter is available perfect for pets who are picky when it comes to eating.

5. cbdMD Pet CBD Oil Tincture for Dogs
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Same CBD Oil benefits as for humans

Low terpene and cannabinoid profile

No THC Animal-specific products (dogs, cats, horses)

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With nothing but MCT oil combined with CBD oil sourced from U.S. hemp that is grown using organic farming methods, these CBD Oil Tinctures for Dogs can be added to their favorite foods while still providing the same effects that you enjoy. We have two flavors to choose from: Natural and Peanut Butter.

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How CBD Helps With Lymphoma in Dogs

Cannabidiol (CBD) is a non-psychoactive drug extracted from the cannabis plant. CBD possesses anti-cancer properties (1) . These benefits may help manage lymphoma in dogs .

A review published in 2016 mentioned that cannabinoids may potentially prevent the growth and spread of cancer cells and stimulate the immune system ’s response against the disease (2) .

CBD is a cannabinoid that comes from the Cannabis sativa plant.

Some trials in the review were conducted on mice. However, one study suggested that CBD may work similarly in other animals, except insects, because the animals’ endocannabinoid system (ECS) functions similarly across all species (3) .

The ECS is located in the animal’s central nervous syste m and is responsible for regulating the body’s balance and maintaining the dog’s quality of life (4) .

The interaction of CBD with the ECS receptors in the nervous and immune systems may have various benefits . These benefits include anti-anxiety effects, anti-inflammatory properties, and potential anti-cancer effects on canines (5) .

There are different types of cancer among dogs, and lymphoma is the most common. Scientists have little understanding of what causes canine lymphoma . However, dogs are exposed to similar environmental factors that cause cancer among humans (6) .

Lymphoma is an umbrella term for any type of cancer that emerges from lymphocytes .

Lymphocytes refer to a group of white blood cells that help fight infection. Lymphocytes are located in the lymphatic system composed of the lymph nodes , bone marrow , and spleen.

Veterinarians diagnose canine cancer by taking a sample of the dog’s lymph nodes or affected organ.

Some vets may also perform staging tests to determine how much the disease has progressed. These tests include blood tests, X -rays, urinalysis, bone marrow aspiration, and abdominal sonograms.

The aggressiveness, survival rates , and symptoms of lymphoma may vary depending on the type of lymphoma . For canine lymphoma , the four most common types are (7) :

  • Multicentric lymphoma – This type of lymphoma is the most common among dogs and is characterized by the rapid enlargement of lymph nodes.

The swelling lymph nodes may grow 3 to 10 times the average size. However, they are not painful and only feel like a firm, rubbery lump under the skin.

As multicentric lymphoma progresses, dogs may show other symptoms, including fever, weakness, lethargy, anorexia, and dehydration.

  • Alimentary lymphoma – This form of canine cancer is the second most common and usually targets the dog’s intestinal organ.

Dogs with alimentary lymphoma may experience vomiting, diarrhea, anorexia, abdominal pain, and weight loss.

  • Extranodal lymphoma – This form of lymphoma affects a specific organ like the eyes, skin, kidneys, or lungs.

Cutaneous lymphoma targets the skin and is one of the common forms of extranodal lymphoma.

Symptoms vary on the area where extranodal lymphoma occurs. For example, cutaneous lymphoma appears as raised nodules or scaly lesions on the skin, lips, or the roof of the mouth.

Extranodal lymphoma occurring in the central nervous system may cause seizures.

Meanwhile, extranodal lymphoma in the bones differs from primary bone cancer because lymphoma does not start in the actual bone cells. Lymphoma in the bones may also cause fractures or pain.

  • Mediastinal lymphoma – This type of cancer in dogs is one of the rare forms of lymphoma. Mediastinal lymphoma affects the mediastinal lymph nodes and the thymus located between the lungs.

Dogs with mediastinal lymphoma may have difficulty breathing because of the tumor growth or fluid accumulation within the chest. Other signs include swelling of the front legs or face, extreme thirst, or urination.

Currently, the most effective cancer treatment for dogs is chemotherapy (8) . The veterinarian’s chemotherapy recommendation may vary depending on the diagnosis or type of lymphoma .

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For example, dogs with multicentric lymphoma may be given the UW-25 chemotherapy protocol.

This protocol is a 25-week chemotherapy session using four chemotherapy drugs known as CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine sulfate (Oncovin), and prednisone).

Typical side effects of chemotherapy in dogs are diarrhea, mild vomiting, reduced appetite, and decreased activity levels (9) .

Benefits and Use of CBD for Lymphoma in Dogs

A study published in The Young Researcher in 2018 mentioned that CBD may be effective in inducing apoptosis (cell death) in many types of cancers , including diffuse large B-cell lymphoma (DLBCL) (10) .

The in vitro study indicated that CBD may have a strong potential to help reduce DLBCL and minimize cancer relapse. However, additional studies in vivo are needed to determine if the results are similar for dogs with lymphoma .

DLBCL is known to be the most common aggressive B-cell lymphoma affecting dogs worldwide (11) .

CBD i s known for its anti-inflammatory properties (12) . These effects may help manage multicentric, extranodal, and mediastinal lymphoma by reducing symptoms such as swelling and inflammation.

CBD also provides analgesic (anti-pain) effects (13) . Such properties may help alleviate pain associated with alimentary or extranodal lymphoma .

CBD Oil Dosage for Dogs With Lymphoma

Currently, there is no Food and Drug Administration-approved dosage guide for CBD products for the management or treatment of canine lymphoma .

However, a 2019 study performed on healthy dogs and cats stated that 2 milligrams of CBD per kilogram of body weight may be a viable dosage with no harmful side effects (14) .

A study in the American Journal of Veterinary Research examined the efficacy of repeated oral administration of CBD among healthy adult beagles (15) .

The study mentioned that doses of 1 to 12mg/kg of CBD administered once daily over 28 days are well tolerated among dogs.

Caution is advised when attempting to administer high doses of CBD in dogs. Higher CBD dosage side effects include dry mouth, drowsiness, or low blood pressure (16) .

You may start with lower doses of CBD for your dog, especially when you are still starting to use CBD for your pet.

Various factors like the dog’s size and weight may influence the CBD dose amount.

Tetrahydrocannabinol ( THC ), another cannabinoid present in some CBD products , has potentially toxic effects on canines at specific doses (17) .

Inform your veterinarian about your dog’s condition before deciding if CBD is suitable for your pet.

However, most states have laws prohibiting veterinarians from prescribing or administering cannabis -based products (18) .

How to Administer CBD for Dog Lymphoma

There are various ways for pet owners to administer CBD products to dogs with lymphoma . Here are some ways dogs may take CBD.

  • CBD oil tinctures are administered sublingually or under the tongue. These tinctures usually come with a dropper or spray for easy administration of CBD to your dogs.

Sublingual administration enables the CBD oil to enter the bloodstream faster, allowing for faster absorption.

CBD tinctures are often mixed with carriers such as hemp seed oil or coconut oil to dilute the CBD.

  • CBD capsules are administered orally, allowing the CBD to pass through the digestive tract before being absorbed by the body.

Another alternative to administer CBD capsules to your dog is to sprinkle the capsule’s contents onto the dog food .

  • CBD edibles such as soft chews, biscuits, or dog treats are also administered orally. These products come in different servings, flavors, and doses.
  • CBD topicals are applied to the dog’s skin. Some topicals for dogs include creams, massage oils, and balms.

How Long Does CBD Take to Help Lymphoma in Dogs ?

Onset times of CBD oil on dogs may vary based on the dosage and route administration.

Sublingual administration using an oromucosal spray or dropper allows CBD to directly enter the bloodstream under the tongue and bypass the digestive tract, leading to faster onset times.

Oral administration by ingesting edibles or capsules allows CBD to pass through the dog’s digestive tract then break down in the liver. This administration method has a slower onset time.

CBD applied topically, such as creams or lotions, may start to take effect depending on the skin thickness. Topicals usually work for skin problems or joint pains and do not get absorbed into the bloodstream.

One study stated that the thickness of the dog’s skin or absorptivity of the CBD-infused topicals may limit transdermal absorption (19) .

Transdermal delivery involves applying CBD topical through the skin so that it is slowly absorbed by the body.

Aside from dosage and administration methods, onset times of CBD products may also vary depending on the dog’s size and weight.

How Long Will CBD Help With Lymphoma in Dogs ?

A 2018 animal study showed that the elimination half-life of a 75mg dose of CBD-infused oil is 199.7 ± 55.9 minutes, while a 75mg dose of CBD micro-encapsulated capsule was at 95.4 ± 29.2 minutes (20) .

Half-life is the duration for the drug’s quantity to be decreased to 50%.

In the same study, the researchers could not ascertain the elimination half-life of 75mg of CBD transdermal creams. This result was due to the lack of an elimination phase in the concentration -time profiles.

Thus, the researchers suggest that additional trials with a more extended period of CBD administration for at least several months be conducted.

Extending the trial duration may provide a better assessment of CBD concentrations and time of effectiveness.

Side Effects and Risks of Using CBD for Lymphoma in Dogs

Some dogs taking CBD may experience diarrhea, vomiting, loss of appetite , or lethargy. Ataxia may also affect the dog’s coordination and balance, especially when CBD is ingested in large doses (21) .

Other side effects of CBD in dogs include dry mouth, drowsiness, and low blood pressure (22) . While these effects may be well tolerated among humans, the pets’ tolerance to these side effects may vary.

One study regarding the safety of increasing CBD doses conducted on beagles mentioned that dogs may tolerate CBD dose volumes of up to 640.5mg or around 64.7mg of CBD per kilogram of the dog’s body weight (23) .

The study also stated that CBD oil formulations with higher CBD content are safer and well tolerated than those with higher THC content.

CBD may inhibit the cytochrome P450 enzyme in the body. If your dog is taking other medication, CBD’s effect may limit or interfere with the drug’s metabolization.

Consider seeking advice from your veterinarian regarding your dog’s condition and medication before purchasing CBD products for your pet.

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How to Shop for the Best CBD Oil for Dogs With Cancer

Dog owners should consider the following factors when looking for high-quality CBD products that may work best for their pets:

  • Extraction method – CBD is extracted from the cannabis plant using CO 2 , ethanol, or hydrocarbon extraction.

CO 2 extraction uses liquefied CO 2 to extract CBD and other components. This method does not use combustible solvents and poses no threat of catching fire (24) .

Ethanol extraction uses ethanol to pull the CBD oil from the hemp plant .

Hydrocarbon extraction uses hydrocarbon solvents like propane or butane for CBD extraction. Hydrocarbons are flammable and may be harmful to the dog’s health if not properly removed from the extracted CBD oil.

  • Cannabinoidcontent – Full-spectrum CBD oil contains all the naturally occurring cannabinoids and compounds in the cannabis plant.

These compounds include THC , terpenes , flavonoids, and fatty acids . Combining these compounds produces an entourage effect that enhances the benefits of CBD oil than when the compounds are taken individually (25) .

However, THC may cause intoxication on canines resulting in stumbling, vomiting, lethargy, agitation, or shaking (26) . Consider broad-spectrum products or isolates as alternatives for your pet.

Broad-spectrum CBD oil has the same cannabinoid content as full-spectrum without the THC .

CBD isolates contain only pure CBD without the other cannabinoids and compounds present.

  • Certificate of analysis (COA) – B rands selling CBD products must have updated COAs accessible on their websites.

The COA shows the CBD product ’s actual cannabinoid content and the presence of pesticides and contaminants, if any.

Credible CBD products must have the details on their labels matched with the COA results.

  • CBD producttype – Dog owners may choose from various CBD products depending on their preferred dosage or route of administration.

CBD oil tinctures are administered sublingually or under the tongue. Edibles like dog treats or chews are taken orally. Capsules are also administered orally. CBD topicals like creams or lotions are applied to the skin.

Legality of CBD

To date, the FDA has not provided approval for cannabis use on dogs. The agency is unable to guarantee the safety and efficacy of these products on animals (27) .

Review your local and state laws regarding the legal consumption of CBD for your dogs before purchasing pet CBD products .

Most states have legislation prohibiting veterinarians from prescribing or administering CBD for dogs (28) .

However, Nevada-based veterinarians may recommend and administer CBD products that contain less than 0.3% THC (29) .

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How can CBD help with lymphoma in dogs?

CBD has anti-inflammatory properties (30) . These benefits may help manage the symptoms of multicentric, extranodal, and mediastinal lymphoma .

CBD also has pain relief effects (31) . Such properties may help reduce pain associated with alimentary and extranodal lymphoma .

What evidence or research exists to say that CBD helps with lymphoma in dogs?

CBD’s anti-cancer properties may help reduce diffuse large B-cell lymphoma (DLBCL) and minimize cancer relapse (32) . However, additional studies must be performed to determine if CBD may help dogs with lymphoma .

DLBCL is known to be the most common aggressive B-cell lymphoma affecting dogs worldwide (33) .

Is there any evidence that CBD can make lymphoma in dogs worse?

To date, there is no evidence of CBD causing canine lymphoma to worsen. However, CBD may have side effects on dogs, such as dry mouth, drowsiness, or low blood pressure (34) .

CBD products containing high levels of THC may be toxic for dogs (35) . Talk to a veterinarian about your dog’s condition and research the THC levels on CBD products before purchasing one for your pet.

Will CBD interact with any current medication taken for lymphoma in dogs?

CBD may interact with other medications by inhibiting the cytochrome P450 enzyme in your dog’s body . This effect may interfere with the metabolization of drugs.

Ask your veterinarian about your dog’s condition and medication before purchasing CBD products for your pet.

Are there other treatments I should consider alongside CBD to help with lymphoma in dogs?

Currently, the most effective cancer treatment option for lymphoma in dogs is chemotherapy (36) . The type of chemo usually depends on the vet’s diagnosis and cancer type.

What is the dosage for lymphoma in dogs?

Currently, there are no FDA-approved doses for CBD products for managing or treating canine lymphoma .

One study mentioned that 2 milligrams per kilogram (mg/kg) of CBD may be a viable dosage for dogs with no harmful side effects (37) .

Do veterinarians recommend CBD for dogs with lymphoma?

Most states have laws prohibiting veterinarians from recommending, prescribing, or administering cannabis -based products for dogs (38) .

In Nevada, veterinarians may recommend and administer CBD products that contain less than 0.3% THC (39) .

Find Relief with CBD Oil for Lymphoma in Dogs

No one wants to discover that their dog has lymphoma, the most common kind of cancer in dogs. Unfortunately, it is the reality for many pet owners. If you have already learned that your dog has lymphoma or fear that it does, read this blog post to learn about the disease and how CBD oil for Lymphoma in dogs may alleviate a lot of emotional and physical pain for your dog and you.

Understanding Lymphoma in Dogs

Lymphoma is a group of cancers that affect humans and dogs that can very simply be described as a cancer of the lymphatic system.

This is a vast and important system in the body that influences the immune system and other crucial bodily functions. Not only does it impact many bodily functions, and therefore interact with many parts of the body, the lymphatic system itself is very complex and dependent on its various parts for each basic function. The whole system and its point for existing depends on movement all over the body, so lymphoma is not as contained as we think of most cancers. It doesn’t start in one place with one tumor

and hopefully stay there for a long time. It is far too likely for lymphoma to spread all over the body, and quickly.

The Lymphatic System

The lymphatic system is a drainage network involved with both the immune and circulatory system. It is made of up several parts, lymph nodes and other organs such as the spleen, appendix, and tonsils, lymph vessels, and lymph fluid. It’s all about the distribution and cleansing of that lymph fluid.

Lymph fluid is a watery substance that escapes from the circulatory system, and it is made of escaped material dogs need and waste materials. The lymph system picks it up and carries it where it needs to go, which takes it all over the body. If not for the lymph system, this fluid would build up in the body, causing swelling and the buildup of toxins.

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While the lymphatic system moves lymph through the body, carrying the good where it needs to go, it also filters out bad things, like germs and toxins. White blood cells are in the lymphatic system, so that immune system action we hear about where white blood

cells attack what isn’t supposed to be in the body goes on in both the blood stream and the lymphatic system.

Canine Lymphoma

Canine lymphoma is a broad term for more the than 30 different types of cancer that attack a dog’s lymphatic system. It is very similar to non-Hodgkin’s lymphoma in people, so similar that the chemotherapy treatment is almost identical.

It begins like other cancers as a single tumor, but because the lymphatic system’s function is to spread fluid all over the body to various organs, it is not likely to stay that way for long.

There are many types of lymphoma, so they, thankfully, do not all spread at the same rate. Some are more contained. Unfortunately, the most common lymphoma in dogs is one that does spread rapidly, multicentric lymphoma.

Canine lymphoma is broken up into stages like human cancers. These are based on the degree to which it has spread through the body.

The World Health Organization has designated the lymphoma stages as follows:
  • Stage I – cancer is contained in a single lymph node
  • Stage II – cancer is contained in multiple lymph nodes on one side of the diaphragm (either the top or the bottom of the dog).
  • Stage III – cancer is only contained in the lymph nodes themselves
  • Stage IV – cancer is located in the liver and spleen or hepatosplenomegaly, whether it started there or spread there.
  • Stage V – cancer is in the bone marrow, central nervous system,

Symptoms of Lymphoma in Dogs

The symptoms of canine lymphoma vary by the type of lymphoma, but there are many common symptoms to be on the lookout for.

The first and most common symptom of canine lymphoma is the presence of a swollen lymph node, or several. This will be a firm, rubbery lump underneath your dog’s skin. Thankfully, a swollen lymph node isn’t painful for the dog.

If you know where their lymph nodes are, you can recognize that it is these nodes that are swollen, and if you don’t already know where your dog’s lymph nodes are, you may want to learn and start getting accustomed to feeling for them while petting your dog. Should one or more of these be swollen, you need to get them to a licensed veterinarian as soon as possible.

Take comfort in the fact that it is not guaranteed that a swollen lymph node means cancer. Like with humans, a simple infection can cause it, but because canine lymphoma is so serious, you should waste no time getting it checked out.

While swollen lymph nodes are the most common symptom, they are not always present or easy to feel. Some lymph nodes are located in places where they may be hard to notice. Your vet may notice them during a routine checkup. You can also take the added precaution of making yourself aware of the other common symptoms of canine lymphoma.

Other common symptoms of lymphoma in dogs:

Because there are so many kinds of lymphoma, some of them have very different symptoms.

Cutaneous lymphoma affects their skin, appearing as dry, red, flaky patches that can spread all over their body. It may be accompanied by masses under the skin. This one is a slower-growing lymphoma.

Gastrointestinal lymphoma affects their digestive system, and its symptoms include diarrhea, vomiting, foul-smelling excrement, and rapid weight loss.

Mediastinal lymphoma appears as labored or otherwise difficult breathing due to either a mass or a fluid buildup.

Traditional Treatments for Canine Lymphoma

Canine lymphoma is not a curable disease. It can go into remission, but that means it is also likely to return. According to the National Canine Cancer Foundation, the median time before lymphoma returns is 6 to 12 months. In 20 to 25% of cases, dogs live 2 years or longer after the cancer has gone into remission, and even if it returns and they undergo a second treatment, they still have a median survival rate of 336 days. That means canine lymphoma treatments may give your dog an additional 3 years of life, or more.

Surgery is not the primary treatment because of the traveling nature of the disease. Chemotherapy is the most common option, with radiation and surgery being used in conjunction sometimes when it is beneficial to treat a mass or specific area.

Veterinarians treat the dog to hopefully make the cancer go into remission or to manage their symptoms so they can enjoy a higher quality of life. If the cancer goes into remission, there will be no detectable signs of the disease and the dog will suffer no more symptoms unless the cancer returns.

It is important to start the treatment as soon as possible. Many pet owners are tempted to put off the chemotherapy because their dog does not act sick yet and they fear the treatments will make them sicker than they have to be, but the treatment is much more effective when begun while the dog is in a healthier state. The cancer has a great likelihood of going into remission, whereas, if you put the treatment off until the dog is suffering, remission may no longer be possible.

IVG hospitals reports that “remission is achieved in 80-90% of dogs and typically lasts 6-9 months. The length of remission depends upon many factors including the primary site of the cancer, how sick an animal is at the start of treatment and the extent of disease.”

They also state that dogs that do not undergo treatment can be expected to live only 1 to 2 months. There is critically short time to treat your dog for canine lymphoma.

Side Effects of Chemotherapy in Dogs

Thankfully, chemotherapy is not as hard on dogs as it is on humans. It is possible that they may not suffer any negative side effects at all.

If your dog does suffer negative side effects of chemotherapy, they may be:

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