CBD Oil And Tamoxifen Interaction

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CBD Oil And Tamoxifen Interaction “Can they be taken at the same time – before bed?” Tamoxifen is a chemotherapy agent commonly used in the treatment of breast cancer. There is a research gap Effect of combining CBD with standard breast cancer therapeutics Breast cancer is the most common malignancy in women worldwide. Sixty-five percent of breast cancers are estrogen and/or

CBD Oil And Tamoxifen Interaction

“Can they be taken at the same time – before bed?”

Tamoxifen is a chemotherapy agent commonly used in the treatment of breast cancer. There is a research gap concerning the anti-tumor effects and effectiveness of cannabis or cannabinoids in treating cancer generally. There is therefore insufficient evidence to support or refute the conclusion that cannabinoids are an effective treatment for cancers.

However, there is conclusive evidence that oral cannabinoids are effective antiemetic in the treatment of chemotherapy-induced nausea and vomiting (Committee on the Health Effect of Marijuana: An Evidence Review and Research Agenda). Cannabis is also well known to be an effective adjuvant analgesic for pain treatment.

Cannabis contains THC and CBD but also compose of over 100 cannabinoids, about 400 terpenes and flavonoids. The interaction of cannabis with most other drugs is not well known. Whatever the reason for which you are consuming cannabis, as a safety measure, I recommend that clients take other drugs and supplements at least two hours apart from cannabis products.

Drug-drug interactions are a potential concern if you are taking more than one medicine at a time. Cannabis and its main cannabinoids, THC, and CBD, may cause drug interactions. Tamoxifen is a “pro-drug,” which means it is not fully effective until it is metabolized by the liver into its more potent anticancer form through a specific metabolic pathway in the liver.

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This metabolic process can be interrupted, inhibited, or even entirely blocked by other substances, includinf Cannabis. Therefore , I would recommend separating these two medications for at least two hours in between.

As others have mentioned, the research regarding drug interactions with cannabis is very limited at this time. As tamoxifen is an antiestrogen that is heavily metabolized in the liver, the potential of an interaction exists.

Cannabis is known to affect liver metabolism via the p450 enzymes, in some cases increasing serum levels of other medications, and sometimes decreasing those levels. Unfortunately, we just don’t have the research at this point to provide a definitive answer.
As always, start low and go slow.

Effect of combining CBD with standard breast cancer therapeutics

Breast cancer is the most common malignancy in women worldwide. Sixty-five percent of breast cancers are estrogen and/or progesterone receptor positive. Estrogen receptor expression is a prognostic and predictive biomarker of response to endocrine therapy, which consists of the selective estrogen receptor modulator tamoxifen, aromatase inhibitors, and the selective estrogen receptor degrader fulvestrant. Cannabidiol is a phytocannabinoid that is emerging as a potential therapeutic agent. The aim of this study was to investigate the effect of cannabidiol on estrogen receptor-positive and estrogen receptor-negative representative breast cancer cell lines in combination with standard therapeutic agents used in clinical practice. To compare the effects of cannabidiol on breast cancer cell viability, cancer cell lines were exposed to increasing concentrations of cannabidiol. The effects of cannabidiol in combination with the endocrine therapeutics tamoxifen, fulvestrant, and the cyclin-dependent kinase inhibitor palbociclib on breast cancer cell viability were examined. We demonstrated that cannabidiol dose-dependently decreased the viability of all breast cancer cell lines independent of estrogen receptor expression. The addition of cannabidiol to tamoxifen had an additive negative effect on cell viability in ER+ ​in estrogen receptor positive T-47D line. Cannabidiol did not attenuate the effect of standard treatment of hormone receptor-positive breast cancer with fulvestrant and palbociclib. In addition, cannabidiol did not attenuate the effect of standard treatment of triple-negative breast cancer and human epidermal growth factor receptor 2 positive breast cancer cell lines with trastuzumab and cisplatin.

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