New research suggests that omega-3 fatty acids can enhance endocannabinoid synthesis. One of the best combinations out there for improving our pet's health and overall well being is a mixture of Omega-3s from fish oil and Cannabidiol (CBD). Omega-3s fish oil contain two essential fatty acids. Cannabidiol (CBD) is a powerful supplement with anti-inflammatory properties and has been proven to have the ability to help control difficult-to-manage symptoms and help treat several previously untreatable conditions. Among other things, CBD oil can help to fight cancer and irritable bowel diseases, improve schizophr
CBD And Fish Oil
Chances are, you’ve probably heard about CBD, and how the many molecules it contains (cannabinoids) can benefit health and wellness. In fact, according to the most recent national poll, 1 in 7 of you reading this article are already using phytocannabinoids (cannabinoids derived from plants) for their various physiological effects and functions. 1
But do you understand how cannabinoids “work” within the body? And did you know that simple adjustments to your diet can promote your body’s natural production of molecules called endocannabinoids? Read on to discover how you can support your endocannabinoid system with or without external sources of cannabinoids.
The Endocannabinoid System: Nature’s Balancing Act
Over the past thirty years, studies exploring the physiological effects of cannabis have led to the discovery of a complex cell signaling network called the endocannabinoid system. 2 – 4 This is a network of lipid (fat)-based signaling molecules called endocannabinoids and the cells that detect them. Importantly, the endocannabinoid system plays an integral role in maintaining balance throughout the body—a vital process called homeostasis. 5
Homeostasis is the ability to maintain a relatively stable internal state despite changes in the external environment. Common examples of homeostatic processes include regulation of body temperature, blood sugar, and blood pressure.
Essentially, whenever an internal function becomes irregular due to injury, insult or illness, a well-functioning endocannabinoid system will respond by synthesizing chemical messengers called endocannabinoids in the brain, organs, connective tissue, glands, and immune cells. 5 These endocannabinoids will then bind with cannabinoid receptors in the central nervous system and immune system to set into motion a variety of cellular responses aimed at restoring balance to the irregular function. 5
Cannabinoid Receptors and Functions
To date, two primary cannabinoid receptors have been identified: CB1 and CB2. Whereas CB1 receptors are found primarily on the surface of cells in the brain and spinal cord, CB2 receptors are largely found on cells in the immune system. 6 Importantly, because these receptors are widely distributed throughout the body, the endocannabinoid system can help regulate the body’s:
- inflammatory response, 7
- perception of pain, 8
- reproductive function, 9
- sleep/wake cycle, 10
- stress response, 11
- mood and anxiety, 12
- immune system, 13 and more. 14
Types of Cannabinoids: Endocannabinoids and Phytocannabinoids
The human body produces a variety of endocannabinoids, some of which are derived from omega-6s, and some of which are derived from omega-3s. The two most well-researched endocannabinoids are anandamide and 2-AG, which come from the omega-6 fatty acid, arachidonic acid. Unlike endocannabinoids, which are synthesized within the body (endo- meaning “within”), THC and CBD are phytocannibinoids—a type of cannabinoid derived from plants (phyto- meaning “relating to plants”). 15 Although there are more than 85 different types of phytocannabinoids known to date, CBD and THC are by far the most well-known and well-researched. 16
THC is considered the mimetic phytocannabinoid of the endocannabinoid anandamide, and similar to anandamide, binds directly to CB1 receptors. 17 Along a similar vein, CBD is considered the mimetic phytocannabinoid of the endocannabinoid 2-AG, and like 2-AG, interacts with both CB1 and CB2 receptors. However, unlike 2-AG, anandamide, and THC—which bind directly to cannabinoid receptors—CBD affects cannabinoid receptors indirectly. 17
Cannabinoids Promote Homeostasis by Influencing Neuronal Communication
The most well-researched homeostatic process that the endocannabinoid system regulates is the speed of communication between cells of the nervous system called neurons. Similar to other neurotransmitters such as dopamine and serotonin, cannabinoids “talk” to neurons in the brain through the release of chemicals. 6
The communication actually occurs when one neuron sends a chemical messenger, or neurotransmitter, to another neuron across a gap called the synapse. Every time a neurotransmitter is sent, this is called neuron firing or transmission. The rate of neuron firing determines the speed that the brain and body can react to various stimuli, but too little or too much firing prevents us from functioning normally. 18 In essence, the endocannabinoid system helps maintain the balance of neuronal transmission by slowing down the rate of neuron firing. Now here comes the really interesting part.
Whereas in most neurotransmitter systems, the sending neuron (pre-synaptic neuron) releases excitatory or inhibitory chemicals across the synapse to the receiving neuron (post-synaptic neuron), in order to slow down neuronal transmission, endocannabinoids are sent in the reverse order—from post-synaptic neuron to pre-synaptic neuron. 6 Then, when endocannabinoids bind to receptors on the pre-synaptic neuron, they inhibit the firing of that neuron. 18 In effect, the endocannabinoid system promotes homeostasis by putting the brakes on neuronal speed by limiting the release of neurotransmitters.
Role of Omega-3 and Omega-6 fats in Endocannabinoid Synthesis and Function
Consuming EPA and DHA can provide many of the same benefits as cannabinoids
Intriguingly, the past fifty years of research on omega-3 fatty acids suggest that consuming an adequate amount of EPA and DHA can provide many of the same benefits as cannabinoids. 19 In truth, this really isn’t that surprising, given that endocannabinoids are lipid-based signaling molecules that are synthesized internally from omega-6 and omega-3 fatty acids. What’s more, research shows that the effects of endocannabinoids can be significantly influenced by the type of fatty acids consumed. 20 , 21 More specifically, their effects can be influenced by the ratios of omega-3 and omega-6 fatty acids consumed.
For example, new research suggests that the consumption of omega-3 fatty acids actually shifts the balance of endocannabinoids towards a higher proportion of omega-3 endocannabinoids (e.g., DHEA, EPEA) as well as endocannabinoid-like molecules that form when omega-3s combine with neurotransmitters like dopamine and serotonin (e.g., DHA-serotonin, EPA-dopamine). 20 Importantly, these omega-3 endocannabinoid and endocannabinoid-like molecules are believed to control vital physiological processes in the body—such as the body’s inflammatory response, pain, and more. 20 , 21
Research also suggests that a diet high in omega-3s can positively influence the neurological functions of the endocannabinoid system. In a study looking at the links between diet, brain functioning, and the endocannabinoid system, researchers fed mice a diet modeled after the Standard American diet—one high in omega-6 fatty acids, and low in omega-3s. Importantly, the omega-3-deficient mice displayed altered brain function and cannabinoid receptor activity in brain areas related to emotional behavior and mood disorders. 22 Put more simply, mice that were deprived of omega-3 fatty acids showed reduced cannabinoid receptor activity and increased depressive behaviors, while these effects were not observed in the mice fed a balanced diet rich in omega-3s.
In light of the reduced endocannabinoid binding and neurological functioning observed in the omega-3-deficient mice, these results suggest that a western diet may have serious implications for neurological health and overall well-being. 22 The good news, however, is that eating a diet with approximately equal ratios of omega-6 and omega-3 fatty acids can help preserve a healthy endocannabinoid system.
Promote Your Health Naturally
Regardless of how you feel about taking external cannabinoids, it is difficult to dispute the benefits of the endocannabinoid system, and its unique ability to restore homeostasis when physiological functions go awry. The fact that research suggests a diet low in omega-3s can disturb cannabinoid function and synthesis, while a diet rich in omega-3 fatty acids can help promote the synthesis of omega-3 endocannabinoids, suggests that simple changes to your diet and/or the addition of omega-3 fish or algae oil can greatly (and naturally!) enhance your health.
Gina Jaeger, PhD is a Developmental Specialist and Lead Research Writer for Nordic Naturals. She holds a doctorate in Human Development, and has published several research articles on children’s cognitive development. Gina enjoys studying and educating others on strategies for optimizing health and wellness throughout the lifespan.
Anandamide and 2-AG: The main two endocannabinoids and are synthesized from omega-6 and omega-3 fatty acids.
Cannabinoids: Molecules derived from fatty acids that binds to cannabinoid receptors.
Cannabis: Any plant of the Cannabis species; does not indicate the presence or absence of the hallucinogenic phytocannabinoid THC.
CB1 and CB2: The two main receptors of the endocannabinoid system, and widely distributed throughout the body. CB1 receptors are primarily found on the surface of cells in the brain and spinal cord, while CB2 receptors are largely found on cells in the immune system.
CBD: Cannabidiol, a phytocannibinoid that acts indirectly on cannabinoid receptors to help restore homeostasis.
Cannabinoid receptors: Cell membrane receptors involved in a variety of physiological processes.
Endocannabinoid System (ECS): Consists of cannabinoid receptors, endocannabinoids, and the metabolic enzymes that synthesize and break endocannabinoids down.
Endocannabinoids: Chemical messengers synthesized by the endocannabinoid system to restore physiological functions.
Homeostasis: Any self-regulating process by which biological systems tend to maintain stability; state of steady internal physical and chemical conditions while adjusting to conditions that are optimal for survival.
Phytocannabinoids: Cannabinoids derived from plants; the most prevalent types are CBD (cannabidiol) and THC (tetrahydrocannabinol).
Pre-synaptic neuron: A nerve cell that sends a chemical messenger, or neurotransmitter, across the synapse.
Post-synaptic neuron: A nerve cell that receives a chemical messenger, or neurotransmitter, after it has crossed the synapse.
Synapse: The site of transmission between a neuron sending a chemical or electric signal to the neuron receiving it.
Benefits Of CBD + Omega-3s Fish Oil For Pet Health
One of the best combinations out there for improving our pet’s health and overall well being is a mixture of Omega-3s from fish oil and Cannabidiol (CBD). Omega-3s fish oil contain two essential fatty acids: EPA and DHA (or eicosapentaenoic acid and docosahexaenoic acid). Both are omega-3 fatty acids that can only be made in a limited capacity in dogs and are even more poorly synthesized in cats. EPA, one of the two omega-3 fatty acids in fish oil, acts as an anti-inflammatory.
EPA may help with conditions that cause inflammation of the heart, kidneys, skin, and joints—such as arthritis. It can ease inflammation due to allergies, and reduce itchy skin and dandruff. This can also be an effective way to potentially decrease the incidence of hot spots on your pets. Like many fat supplements, it promotes a shiny, healthy coat, and reduces shedding. DHA, the other omega-3 fatty acid in fish oil, is important in brain and eye development in puppies and kittens. Giving fish oil to pregnant or nursing pets may also benefit the babies once they’re born.
Cannabidiol (CBD) is not just beneficial for humans. Pets have the same endocannabinoid system as humans, allowing our furry best friends to benefit from CBD as well. CBD oil may have a relaxing, calming effect on our pets while reducing their anxiety which is helpful in pets with separation anxiety and various noise phobias. CBD Oil, like Omega-3s, is an anti-inflammatory that may help relieve joint discomfort. Also like Omega-3s, CBD supports cardiovascular function and helps promote a healthy heart.
In summary, we recommend giving your pet, whether young or old, CBD and a high quality Omega-3 rich source such as Wild Alaskan Salmon Oil daily. Our Pets by TerraVita tincture is formulated with THC-Free CBD Isolate and Wild Alaskan Salmon oil.†
Why CBD & Omega-3?
Cannabidiol (CBD) is a powerful supplement with anti-inflammatory properties and has been proven to have the ability to help control difficult-to-manage symptoms and help treat several previously untreatable conditions. Among other things, CBD oil can help to fight cancer and irritable bowel diseases, improve schizophrenia symptoms, relieve anxiety, and enhance the quality of sleep.
Of all the benefits offered by CBD, natural pain relief tops the list for many. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. Some studies, including an investigation published in the Journal of Experimental Medicine, found that CBD significantly reduces inflammation in mice and rats – but it’s not only rodents that experience these effects. A 2008 review identified that CBD offered effective pain relief without inducing adverse side effects in patients.
One of the most important health benefits of CBD oil is its analgesic (pain relieving) effects. It’s thought that CBD interacts with receptors in the brain and immune system to reduce inflammation and alleviate pain.
Seizures occur when there’s a dramatic fluctuation of electrical activity in the brain. Over the years, several high profile cases have raised awareness of CBD’s anti-seizure properties, but it’s only recently that science has been able to confirm this link.
While CBD is most commonly used to treat physiological symptoms, there’s a growing body of research that indicates it can also be useful as part of the treatment regimens for a range of mental health conditions, including anxiety.
Research indicates that CBD may be valuable in the treatment of cancer in many different ways. CBD, in addition to some of the other compounds found in cannabis, has an antitumor effect and can amplify the death of tumor cells in both colon cancer and leukemia.
Reduces the risk for Diabetes
CBD oil may reduce the risk of developing Diabetes. In a recent study, researchers set out to explore what effect CBD would have on non-obese, diabetes-prone female mice. Only 32 percent of the mice that received the CBD were diagnosed with Diabetes, compared to 100 percent of the untreated group.
CBD + Omega-3
CBD oil works by interacting with the body’s endocannabinoid system (ECS), which is a physiological system made up of neurotransmitters named endocannabinoids. These chemical messengers bind to and activate cannabinoid receptors, which triggers a multitude of critical physiological responses involved in the regulation of inflammation, pain, fertility, appetite, memory, and mood, among other biological processes. The cannabinoids present in CBD oil are also able to activate these cannabinoid receptors – and therefore, like our bodies’ own endocannabinoids, are able to exert positive effects on our health and wellbeing.
So Why Omega-3 + CBD?
In order to get the most out of our CBD supplements, the phytocannabinoids require a fat source in order to reach and stimulate the endocannabinoid receptors. Consuming CBD with a high-quality omega-3 supplement will dramatically increase the effects of your CBD supplement.
Evidence also indicates that omega-3 plays a crucial role in maintaining the proper functioning of your endocannabinoid system.
Most importantly, omega-3 helps to maintain your ECS by:
- Maintaining and repairing cannabinoid receptors
- Providing the body with the ingredients necessary to grow more cannabinoid receptors
- Helping the body to synthesize endocannabinoids
- Keeping the body’s omega-6 to omega-3 ratio low, which helps to maintain healthy receptor membranes
- Aids in the conversion of one type of cannabinoid to another as needed
- Helps to metabolically regulate the ECS by creating the enzymes that produce and degrade cannabinoids
For these reasons, it is vital to note that the only way for your body to reap the full range of benefits provided by CBD is to ensure that your dietary and/or supplementary intake of omega-3 is sufficient.
Who can benefit from CBDO3?
CBDO3 combines two of the worlds most powerful natural anti-inflammatory health products. Working together these ingredients complement one another and improve one another’s efficacy simultaneously. This product is ideal for people looking to relieve, stress and anxiety, to help improve sleep and focus. CBDO3’s high potency omega-3’s will help reduce inflammation in the body all while carrying the phytocannabinoids to the endocannabinoid receptors to promote healing and wellness in the body. This product is unique in the sense that its effects can be felt nearly immediately. So if you are looking to improve your health or relieve or alleviate any condition named above this CBDO3 is the product for you.