Before You Take CBD, Read This (The Grapefruit Effect) You’re ready to try CBD. You’ve hit the point where you’re curious enough, or desperate enough, or educated enough to try it. There’s Does CBD interact with other drugs and medications? Yes – in both positive and negative ways. See which medicines you should be careful with and how you can test it.
Before You Take CBD, Read This (The Grapefruit Effect)
You’re ready to try CBD. You’ve hit the point where you’re curious enough, or desperate enough, or educated enough to try it.
There’s just one thing you need to know before you dive in:
While CBD is incredibly safe, it can interact with other medications you’re currently taking.
The Grapefruit Warning
Has your doctor told you to avoid grapefruit juice while taking your current medications? If so, CBD may not be for you (for now).
CBD, like grapefruit, interacts with certain medications in a way that can be dangerous. Forbes explains this effect well:
The reason for the warning is that grapefruit contains compounds called furanocoumarins that bind with and effectively neutralize enzymes in the gut (specifically a type called CYP450 enzymes), which help break down and eliminate drugs from the body. When these enzymes can’t do their job, too much of the drug enters the liver and flows unprocessed into the bloodstream. That elevates risk of having dangerously high levels of the drug in your system.
When should I avoid CBD?
From Drugs.com, “Examples of some of the most common grapefruit or grapefruit juice drug interactions include:”
- fentanyl transdermal system
While we’re big fans of CBD here at Holden Farms, we’re even bigger fans of health. Please be safe as you determine whether CBD is right for you!
- Tags: grapefruit, warnings
Statements have not been evaluated by the Food and Drug Administration.
CBD products not intended to diagnose, treat, cure, or prevent any disease.
CBD and Drug Interactions
The answer is yes, Cannabis can interact with certain medications in positive and negative ways. CBD is generally safe to use but it is also known to have a few side effects. This is especially true when taking large doses of CBD. We already know that cannabis can interact with other foods and drinks such as mangoes and coffee. It’s also worth noting that if you are taking any medications, CBD can also potentially interact with them. We will explain everything you need to know about how to safely use CBD if you are also taking other medications.
How Does CBD Interact With Certain Medications?
The way that your body metabolizes CBD can interfere with how your body will metabolize other medicines you take. If the medication you are taking does not get metabolized properly, it will linger in your body for a long amount of time, causing negative side effects and even complications. In particular, this can be an issue with blood thinners such as Warfarin. Taking Warfarin with CBD can make the Warfarin stay in your system for too long. Because Warfarin thins your blood and limits the ability for blood to clot, any individual consuming a CBD product should pay close attention to changes in blood levels of Warfarin, and adjust their dosage as instructed by their healthcare provider.
There Are Some Good Interactions
Just because CBD interacts with certain medications doesn’t necessarily mean it’s always a bad interaction. In fact, CBD can make other drugs more effective, sometimes enabling people to lower their current medication dose, which can ultimately reduce any uncomfortable side effects.
What is the Grapefruit Test?
The Grapefruit Test is a simple way to understand if CBD could interact with your medications.
If your doctor tells you that you can’t eat grapefruit with your medication, you should be careful about combining it with CBD. Do your research. Does CBD break down in the same way as a grapefruit? Is it still safe to take CBD and eat grapefruit with medications?
The Grapefruit Test
Adrian Lee of Project CBD describes this Grapefruit Test. CBD interacts with other medications in your body in the same way as grapefruit. If you are advised by your health care provider not to take your medication with grapefruit then it’s probably advisable to avoid using CBD with it.
There is a family of compounds in our body called cytochrome P450. This compound interferes with the metabolism of certain medications. CBD also interacts with the same compound.
Simply ask your doctor if it’s safe to eat grapefruit while taking this medication. Chances are, they will know exactly what you are talking about. Remember that if your health care provider advises you to avoid grapefruits with your medication, you should be cautious about taking CBD with it.
The grapefruit test is a good way to tell if it is safe to mix CBD with any medication especially if the person prescribing the medication is not familiar with CBD. However, we always recommend that you tell your doctor you want to use CBD. It is advisable to let your doctor know about any medicine you are taking or planning to take, even he or she does not normally prescribe cannabis.
If your doctor is aware of your CBD usage, it may be easier to get detailed advice on how to combine CBD with your medication, or if you need to take any medication at all while using CBD. Your doctor may also decide to monitor your blood work closely or advise you to avoid taking CBD at the same exact time of the day that you take your other medication. It’s always best to speak with your doctor before taking ANY supplements or medications.